Verapamil for Neuroprotection in Stroke
Sponsored by Global Neurosciences Institute
About this study
The purpose of this research study is to test an experimental procedure called intra-arterial delivery of verapamil in patients diagnosed with acute ischemic stroke. This study investigates the safety of intra-arterial delivery of verapamil, a drug used to treat vasospasm (spasm of a blood vessel), and how it affects recovery from stroke. Recruitment is limited to patients that have received mechanical thrombectomy as standard of care.
Where this study is enrolling (2)
- I'm interested
AtlantiCare Regional Medical Center
Atlantic City, New Jersey
- I'm interested
St Mary Medical Center
Langhorne, Pennsylvania
Who can participate
Inclusion criteria
- ✓Written informed consent
- ✓18 years of age and over
- ✓Acute onset focal neurologic deficit consistent with acute ischemic stroke, or computed tomographic scan consistent with acute cerebral ischemia
- ✓Candidate for mechanical thrombectomy procedure
- ✓Onset of symptoms less than 8 hours
- ✓Measurable neurologic deficit (NIHSS ≥4)
- ✓Willingness to follow up with rehabilitation therapy
- ✓Anticipated life expectancy of at least 3 months
Exclusion criteria
- ✕Pregnancy or suspected pregnancy (pregnancy test will be done on women of child-bearing potential)
- ✕Hepatic and/or renal insufficiency (LFT's\>3× upper limit of normal; CrCl \< 30ml/min)
- ✕Thrombocytopenia (platelet count \<75,000/mm3)
- ✕History of intolerance to verapamil
- ✕Previous functional disability (modified Rankin \> 1)
- ✕Severe stroke (NIHSS\>22)
- ✕Stuporous or comatose
- ✕Unlikely to be available for 90 day follow-up
Only the research team can confirm whether you qualify. The intake questionnaire is the best way to find out.
Completing a questionnaire on Clinably does not enroll you in a clinical trial or confirm your eligibility. Only the research team can determine whether you qualify to participate. These results are based on the information you provide and are intended to help you start a conversation with the research team.
Trial data sourced from ClinicalTrials.gov.